I usually run a few test songs at the venue I'm at before deciding on a setting, so I can get the sound I want.
That said, I find myself commonly using the '+' position on the B2, and the low/high volume preset on the T1. I'm always changing the 3 tone settings.
I only ever change the bass switch if the room is causing too much bass, which usually isn't a problem. In addition to the Dj presets, I also use an eq bump around 15Khz to open it up a tad more. If I'm doing something extremely loud I usually roll of the high end though, as it gets a tad shouty if I don't.
I'm using 2 L1 M2 with 2 B2. Usually I use the + option on both. I'm not using the T1 anymore since I have 2 Systems and go direct into the Keyboard. In very small rooms I change to the normal position but most of the time the + option is great and I think about buying 2 packlite and 2 more B2s. For Outside Gigs this would be great I think.
I have four B2s and two T-1s (2 L1 Model II) and two packlites that I run into my Pioneer controller, DDJ-SZ. On both T-1s, I run them on DJ low volume preset, B2 selectable button on the plus setting. Just imagine how that sounds, clean and powerful:-).