I set up Alexa in Bose Music App for my Home Speaker 300. I ask Alexa to play music and tells me to add the Smart Home Skill in the Alex iPhone app for the speaker. It won't even change tracks when a preset linked to Amazon Music is playing. I've remove Alexa today after updating my Bose Music App and powering the speaker off and on then set Alexa up again. It still doesn't work When I try that skill via Alex phone app it adds it to the shoping list. When I get phone app or speaker's Alexa to add the skill to the speaker it come back with the Bose Touch Speaker app which is not for the Home Speaker 300 and I don't have an account for that. Speaker works with Bose music app though I prefer the Bluetooth since the Amazon Music app as I can get back to a list of all songs in a playlist to jump around to another song.
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